Human IgE response: virus-activated IgE secretors are interleukin-2-dependent cells.


The activation of human IgE-secreting B lymphocytes was difficult until the use of low cell density limiting dilution cultures, which are more efficient and eliminate regulatory growth restraints, became possible. The transformation of IgE-producing cells by Epstein-Barr virus unexpectedly required the presence of small supplements of mature T lymphocytes… (More)


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