Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.

@article{Verreck2004HumanIT,
  title={Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.},
  author={Frank A. W. Verreck and Tjitske de Boer and Dennis M. L. Langenberg and Marieke A. Hoeve and Matthijs Kramer and Elena Vaisberg and Robert Kastelein and Arend Kolk and Ren{\'e} de Waal-Malefyt and Tom H. M. Ottenhoff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 13},
  pages={4560-5}
}
Macrophages (Mphi) play a central role as effector cells in immunity to intracellular pathogens such as Mycobacterium. Paradoxically, they also provide a habitat for intracellular bacterial survival. This paradoxical role of Mphi remains poorly understood. Here we report that this dual role may emanate from the functional plasticity of Mphi: Whereas Mphi-1 polarized in the presence of granulocyte-Mphi colony-stimulating factor promoted type 1 immunity, Mphi-2 polarized with Mphi colony… CONTINUE READING
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