Human IL-19 regulates immunity through auto-induction of IL-19 and production of IL-10.

@article{Jordan2005HumanIR,
  title={Human IL-19 regulates immunity through auto-induction of IL-19 and production of IL-10.},
  author={William James Jordan and Joyce Eskdale and Michele Boniotto and Greig Patrick Lennon and Jon Peat and John D Campbell and Grant Gallagher},
  journal={European journal of immunology},
  year={2005},
  volume={35 5},
  pages={1576-82}
}
IL-19 is a novel, recently identified member of the IL-10 family of cytokines. We identified IL-10 as a cytokine that was strongly induced in IL-19-stimulated PBMC. IL-19-induced IL-10 secretion was dose-dependent and could be detected in culture supernatants after 3 h of stimulation. Furthermore, quantitative RT-PCR analysis demonstrated that IL-19 stimulation increased the level of IL-10 mRNA present within cells, suggesting that IL-19 is a transcriptional activator of IL-10. IL-19 was also… CONTINUE READING
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