Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.

@article{Lipiski2013HumanHA,
  title={Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.},
  author={Miriam Lipiski and Jeremy W. Deuel and Jin Hyen Baek and Wolfgang R Engelsberger and Paul B{\"u}hler and Dominik J Schaer},
  journal={Antioxidants & redox signaling},
  year={2013},
  volume={19 14},
  pages={1619-33}
}
AIMS Infusion of purified haptoglobin (Hp) functions as an effective hemoglobin (Hb) scavenging therapeutic in animal models of hemolysis to prevent cardiovascular and renal injury. Epidemiologic studies demonstrate the phenotype heterogeneity of human Hp proteins and suggest differing vascular protective potential imparted by the dimeric Hp1-1 and the polymeric Hp2-2. RESULTS In vitro experiments and in vivo studies in guinea pigs were performed to evaluate phenotype-specific differences in… CONTINUE READING
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