Human Host Factors Required for Influenza Virus Replication

  title={Human Host Factors Required for Influenza Virus Replication},
  author={Ronny K{\"o}nig and Silke Stertz and Yingyao Zhou and Atsushi Inoue and H.-Heinrich Hoffmann and Suchita Bhattacharyya and Judith G. Alamares and Donna M. Tscherne and Mila Brum Ortigoza and Yuying Liang and Qinshan Gao and Shane E. Andrews and Sourav Bandyopadhyay and Paul D. De Jesus and Buu P. Tu and Lars Pache and Crystal Shih and Anthony P. Orth and Ghislain M C Bonamy and Loren J Miraglia and Trey Ideker and Adolfo Garc{\'i}a-Sastre and John A. Young and P. Palese and Megan L Shaw and Sumit K. Chanda},
Influenza A virus is an RNA virus that encodes up to 11 proteins and this small coding capacity demands that the virus use the host cellular machinery for many aspects of its life cycle. Knowledge of these host cell requirements not only informs us of the molecular pathways exploited by the virus but also provides further targets that could be pursued for antiviral drug development. Here we use an integrative systems approach, based on genome-wide RNA interference screening, to identify 295… CONTINUE READING
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Influenza A virus entry into cells lacking sialylated N-glycans.

Proceedings of the National Academy of Sciences of the United States of America • 2012
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