Human HSP70 promoter contains at least two distinct regulatory domains.

@article{Wu1986HumanHP,
  title={Human HSP70 promoter contains at least two distinct regulatory domains.},
  author={Ben Juan Wu and Robert E. Kingston and Richard I. Morimoto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 3},
  pages={629-33}
}
The expression of the human HSP70 gene is induced by a wide range of physiological stresses, including exposure to heat shock and heavy metals, or under nonstress conditions, such as in response to serum stimulation. We have previously demonstrated that in either case the regulated expression is at the primary level of transcription. To determine whether transcription is mediated through a single or multiple genetic elements, we have dissected the sequences upstream of the transcription start… CONTINUE READING