Human HLA-DR beta gene hypervariable region homology in the biobreeding BB rat: selection of the diabetic-resistant subline as a rheumatoid arthritis research tool to characterize the immunopathologic response to human type II collagen

@article{Watson1990HumanHB,
  title={Human HLA-DR beta gene hypervariable region homology in the biobreeding BB rat: selection of the diabetic-resistant subline as a rheumatoid arthritis research tool to characterize the immunopathologic response to human type II collagen},
  author={W. C. Watson and James P. Thompson and Kuniaki Terato and M. A. Cremer and Andrew Kang},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={172},
  pages={1331 - 1339}
}
Collagen arthritis (CA), an autoimmune model of rheumatoid arthritis (RA), has been studied in various animals. However, it has not been studied in an animal with a genetic background relevant to RA. We selected rats from a diabetic-resistant (DR) subline of the diabetic BB rat because they have an autoimmune disease-prone background, but not the… CONTINUE READING