Human Gut Microbiome: Function Matters.

  title={Human Gut Microbiome: Function Matters.},
  author={Anna Heintz‐Buschart and Paul Wilmes},
  journal={Trends in microbiology},
  volume={26 7},

Metaproteomic analysis of human gut microbiome in digestive and metabolic diseases.

Human Microbiome Acquisition and Bioinformatic Challenges in Metagenomic Studies

Methods standardization and the development of specific pipelines for data analysis are required to contribute to and increase the understanding of the human microbiome relationship with health and disease status.

An Integrated Multi-Disciplinary Perspective for Addressing Challenges of the Human Gut Microbiome

A perspective review of the recent literature that focuses on the challenges of exploring the human gut microbiome, with a strong focus on an integrated perspective applied to these themes, contextualize the experimental and technical challenges of undertaking such studies and provide a framework for capitalizing on the breadth of insight such approaches afford.

Avian gut microbiomes taking flight.

Stable-Isotope Probing of Human and Animal Microbiome Function




The human microbiome: at the interface of health and disease

The large-scale dynamics of the microbiome can be described by many of the tools and observations used in the study of population ecology, andiphering the metagenome and its aggregate genetic information can also be used to understand the functional properties of the microbial community.

Relating the metatranscriptome and metagenome of the human gut

This work conducted what is, to their knowledge, one of the first human microbiome studies in a well-phenotyped prospective cohort incorporating taxonomic, metagenomic, and metatranscriptomic profiling at multiple body sites using self-collected samples.

Microbiome-wide association studies link dynamic microbial consortia to disease

An appreciation of the complexity of interactions among the microbiome and the host's diet, chemistry and health, as well as determining the frequency of observations that are needed to capture and integrate this dynamic interface, is paramount for developing precision diagnostics and therapies based on the microbiome.

Shotgun metaproteomics of the human distal gut microbiota

This work used a non-targeted, shotgun mass spectrometry-based whole community proteomics, or metaproteomics, approach for the first deep proteome measurements of thousands of proteins in human fecal samples, thus demonstrating this approach on the most complex sample type to date.

Functional profiling of the gut microbiome in disease-associated inflammation

Functional profiling of the human microbiome using metagenomic and metatranscriptomic approaches is discussed, focusing on the implications for inflammatory conditions such as inflammatory bowel disease and rheumatoid arthritis.

Strain-level dissection of the contribution of the gut microbiome to human metabolic disease

It is argued that if a causative role can be demonstrated in follow-up mechanistic studies—for example, using gnotobiotic models—such functional strains have the potential to become biomarkers for diagnostics and targets for therapeutics.

Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes

This work presents an integrative approach to resolve the taxonomic and functional attributes of gastrointestinal microbiota at the metagenomic, metatranscriptomic and metaproteomic levels and applies it to samples from four families with multiple cases of type 1 diabetes mellitus.

Structure, Function and Diversity of the Healthy Human Microbiome

The Human Microbiome Project has analysed the largest cohort and set of distinct, clinically relevant body habitats so far, finding the diversity and abundance of each habitat’s signature microbes to vary widely even among healthy subjects, with strong niche specialization both within and among individuals.