Human Golgi antiapoptotic protein modulates intracellular calcium fluxes.

  title={Human Golgi antiapoptotic protein modulates intracellular calcium fluxes.},
  author={Fabrizio de Mattia and Caroline Gubser and Michiel M. T. van Dommelen and Henk-Jan Visch and Felix Distelmaier and Antonio Postigo and Tomas Luyten and Jan B Parys and Humbert de Smedt and Geoffey L Smith and Peter H. G. M. Willems and Frank J M van Kuppeveld},
  journal={Molecular biology of the cell},
  volume={20 16},
Golgi antiapoptotic protein (GAAP) is a novel regulator of cell death that is highly conserved in eukaryotes and present in some poxviruses, but its molecular mechanism is unknown. Given that alterations in intracellular Ca(2+) homeostasis play an important role in determining cell sensitivity to apoptosis, we investigated if GAAP affected Ca(2+) signaling. Overexpression of human (h)-GAAP suppressed staurosporine-induced, capacitative Ca(2+) influx from the extracellular space. In addition, it… CONTINUE READING
30 Citations
27 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 30 extracted citations


Publications referenced by this paper.
Showing 1-10 of 27 references

Ca2 exchange restores agonist-induced ATP production and Ca2 handling in human complex I deficiency

  • C. White, C. Li, +4 authors J. K. Foskett
  • J. Biol. Chem
  • 2005
Highly Influential
6 Excerpts

IP 3 receptors in cell survival and apoptosis : Ca 2  release and beyond

  • N. N. Kasri, S. L. Kocks, +5 authors H. De Smedt
  • 2007

, necrosis and mi - toptosis

  • H. J. Visch, W. J. Koopman, +5 authors P. H. Willems
  • 2006
1 Excerpt

Similar Papers

Loading similar papers…