Corpus ID: 43574542

Human Genome data analyzed by an evolutionary method suggests a decrease in cerebral protein-synthesis rate as cause of schizophrenia and an increase as antipsychotic mechanism

  title={Human Genome data analyzed by an evolutionary method suggests a decrease in cerebral protein-synthesis rate as cause of schizophrenia and an increase as antipsychotic mechanism},
  author={Hans Moises},
  journal={arXiv: Disordered Systems and Neural Networks},
  • H. Moises
  • Published 2001
  • Physics, Biology, Mathematics
  • arXiv: Disordered Systems and Neural Networks
The Human Genome Project (HGP) provides researchers with the data of nearly all human genes and the challenge to use this information for elucidating the etiology of common disorders. A secondary Darwinian method was applied to HGP and other research data to approximate and possibly unravel the etiology of schizophrenia. The results indicate that genetic and epigenetic variants of genes involved in signal transduction, transcription and translation - converging at the protein-synthesis rate… Expand
The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia
The hypothesis suggests glial cells as the locus of the genes-environment interactions in schizophrenia, with glial asthenia as an important factor for the genetic liability to the disorder, and an increase of prolactin and/or insulin as possible working mechanisms of traditional and atypical neuroleptic treatments. Expand
Etiology of schizophrenia and therapeutic options.
The theory that encompasses most of the properties of SCH is the hypothesis on reduced central protein synthesis, but it still requires many control studies and clearly defining the aetiology of schizophrenia would result in significant progress in diagnosis and treatment. Expand
Schizophrenia: a review of neuropharmacology
The ideal treatment for schizophrenia may not be a single pharmacological agent but several agents that match the different expressions of the illness, in combination with psycho-social interventions. Expand


A re-evaluation of the viral hypothesis: is psychosis the result of retroviral integration at a site close to the cerebral dominance gene?
  • T. Crow
  • Biology, Medicine
  • The British journal of psychiatry : the journal of mental science
  • 1984
It is proposed that onset of disease is due to the expression of a 'provirus', which is integrated in the genome, having been acquired either by prenatal infection or in the germ-line from an affected parent; this could explain why the season of birth effect is accentuated in patients without a family history of the disease. Expand
Genes, environment and schizophrenia.
Schizotaxia provides a useful way to conceptualise both the liability for schizophrenia, and also the development of treatment strategies aimed at the eventual prevention of the illness. Expand
Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis.
The results suggest the existence, on chromosome 18p, of a potential susceptibility locus for functional psychoses, and the existence of association/linkage disequilibrium in the presence of linkage. Expand
Further investigation of a chromosome 15 locus in schizophrenia: analysis of affected sibpairs from the NIMH Genetics Initiative.
The results further support the involvement of this chromosomal locus in the genetic transmission of schizophrenia. Expand
Genome Scan for Susceptibility Loci for Schizophrenia
The result supports the notion that there is possibly some consistent evidence for replicated linkage of a schizophrenia susceptibility locus around the region of D6S309 at chromosome 6p24. Expand
Viruses and Schizophrenia
  • R. O'reilly
  • Medicine
  • The Australian and New Zealand journal of psychiatry
  • 1994
Advances in understanding of the pathophysiology of viral diseases and the development of sophisticated techniques to study them have resulted in more complex viral hypotheses of schizophrenic aetiology, such as viral disruption of normal neurodevelopment, viral induced autoimmunity and retroviral integration. Expand
Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes.
Using a systematically ascertained sample of 57 families, each having 2 or more members with a consensus diagnosis of schizophrenia (DSM-III-R criteria), linkage studies of 520 loci identified regions for further exploration as potential sites of susceptibility genes for schizophrenia. Expand
Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes
The identification of multiple susceptibility loci for schizophrenia may be enhanced by stratification of families using psychiatric diagnoses of the non-schizophrenic relatives. Expand
A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci.
The results from a three-stage genomewide screen performed in a study sample from an internal isolate of Finland suggest that there are several putative loci predisposing to schizophrenia, even in this isolate. Expand
Endogenous retroviruses and schizophrenia
Evidence for a possible role of endogenous retroviruses in the etiopathogenesis of schizophrenia and other human brain diseases is discussed and the delineation of a role for retrovirus in disease pathogenesis might lead to new methods for the diagnosis and treatment of schizophrenia. Expand