Human Genome and Diseases:¶Apaf1 in developmental apoptosis and cancer: how many ways to die?

  title={Human Genome and Diseases:¶Apaf1 in developmental apoptosis and cancer: how many ways to die?},
  author={Francesco Cecconi and P. Gruss},
  journal={Cellular and Molecular Life Sciences CMLS},
Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an… CONTINUE READING


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