Human Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA Nanoarrays

@article{Drmanac2010HumanGS,
  title={Human Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA Nanoarrays},
  author={R. Drmanac and Andrew B. Sparks and M. J. Callow and A. Halpern and Norman Burns and B. Kermani and Paolo Carnevali and I. Nazarenko and Geoffrey B. Nilsen and George Yeung and Fredrik Dahl and Andr{\'e}s Fern{\'a}ndez and Bryan P. Staker and K. Pant and J. Baccash and Adam P Borcherding and Anushka Brownley and R. Cedeno and L. Chen and Dan Chernikoff and A. Cheung and R. Chirita and B. Curson and Jessica C. Ebert and C. Hacker and Robert B. Hartlage and B. Hauser and S. Huang and Y. Jiang and Vitali Karpinchyk and M. Koenig and Calvin Kong and T. Landers and Catherine Le and Jia Liu and Celeste McBride and Matt Morenzoni and Robert E Morey and Karl Mutch and Helena Perazich and K. Perry and B. Peters and Joe Peterson and C. Pethiyagoda and Kaliprasad Pothuraju and C. Richter and A. M. Rosenbaum and Shaunak Roy and Jay Shafto and Uladzislau Sharanhovich and K. Shannon and C. Sheppy and M. Sun and J. Thakuria and A. Tran and D. Vu and A. W. Zaranek and X. Wu and S. Drmanac and Arnold R. Oliphant and W. Banyai and Bruce Martin and D. Ballinger and G. Church and C. Reid},
  journal={Science},
  year={2010},
  volume={327},
  pages={78 - 81}
}
  • R. Drmanac, Andrew B. Sparks, +62 authors C. Reid
  • Published 2010
  • Biology, Medicine
  • Science
  • Toward $1000 Genomes The ability to generate human genome sequence data that is complete, accurate, and inexpensive is a necessary prerequisite to perform genome-wide disease association studies. Drmanac et al. (p. 78, published online 5 November) present a technique advancing toward this goal. The method uses Type IIS endonucleases to incorporate short oligonucleotides within a set of randomly sheared circularized DNA. DNA polymerase then generates concatenated copies of the circular… CONTINUE READING
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