Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

@article{Regl2002HumanGA,
  title={Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma},
  author={Gerhard Regl and Graham W. Neill and Thomas Eichberger and Maria Kasper and Mohammed S. Ikram and Josef Koller and Helmut Hintner and Anthony G. Quinn and A. -M. Frischauf and Fritz Aberger},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={5529-5539}
}
Transgenic mouse models have provided evidence that activation of the zinc-finger transcription factor GLI1 by Hedgehog (Hh)-signalling is a key step in the initiation of the tumorigenic programme leading to Basal Cell Carcinoma (BCC). However, the downstream events underlying Hh/GLI-induced BCC development are still obscure. Using in vitro model systems to analyse the effect of Hh/GLI-signalling in human keratinocytes, we identified a positive feedback mechanism involving the zinc finger… CONTINUE READING
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