Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration

@article{Maecki2019HumanFI,
  title={Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration},
  author={Jędrzej M. Małecki and Hanneke L D M Willemen and Rita Pinto and Angela Yeuan Yen Ho and Anders Moen and Niels Eijkelkamp and P{\aa}l {\O}. Falnes},
  journal={The Journal of Biological Chemistry},
  year={2019},
  volume={294},
  pages={11654 - 11664}
}
Lysine methylation is a common posttranslational modification of nuclear and cytoplasmic proteins but is also present in mitochondria. The human protein denoted “family with sequence similarity 173 member B” (FAM173B) was recently uncovered as a mitochondrial lysine (K)-specific methyltransferase (KMT) targeting the c-subunit of mitochondrial ATP synthase (ATPSc), and was therefore renamed ATPSc-KMT. We here set out to investigate the biochemical function of its yet uncharacterized paralogue… 

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