Human Ether-à-go-go–related Gene K+ Channel Gating Probed with Extracellular Ca2+

  title={Human Ether-{\`a}-go-go–related Gene K+ Channel Gating Probed with  Extracellular Ca2+   },
  author={J. Johnson and Franklin M. Mullins and Paul B. Bennett},
  journal={The Journal of General Physiology},
  pages={565 - 580}
Human ether-à-go-go-related gene (HERG) encoded K+ channels were expressed in Chinese hamster ovary (CHO-K1) cells and studied by whole-cell voltage clamp in the presence of varied extracellular Ca2+ concentrations and physiological external K+. Elevation of external Ca2+ from 1.8 to 10 mM resulted in a reduction of whole-cell K+ current amplitude, slowed activation kinetics, and an increased rate of deactivation. The midpoint of the voltage dependence of activation was also shifted +22.3 +/- 2… CONTINUE READING
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