Human Embryos Genetically Modified: A Review

@inproceedings{Lakra2016HumanEG,
  title={Human Embryos Genetically Modified: A Review},
  author={Vibhuti Astha Lakra},
  year={2016}
}
The modification of an organism, “genetically” is been a fascinating field of research for researcher for long time. Much of research is done in terms of Gene Editing and Genetic Modification. Tools such as chemicals and radiation to cause mutations are now outdated as it used to cost a lot of time and money. The efficiency was also not to the level to which it was desired as researchers were unable to target the specific position that they wanted in the genome. For Gene editing it’s a new era… Expand

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References

SHOWING 1-10 OF 161 REFERENCES
CRISPR: gene editing is just the beginning
TLDR
The phones have been ringing a lot since early 2013, when researchers first reported 1–3 that they had used the CRISPR– Cas9 system to slice the genome in human cells at sites of their choosing. Expand
Correction of a genetic disease in mouse via use of CRISPR-Cas9.
TLDR
It is shown that mice with a dominant mutation in Crygc gene that causes cataracts could be rescued by coinjection into zygotes of Cas9 mRNA and a single-guide RNA targeting the mutant allele, and were fertile and able to transmit the corrected allele to their progeny. Expand
Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
TLDR
By coinjection of Cas9 mRNA and sgRNAs into one-cell-stage embryos, this system successfully achieves precise gene targeting in cynomolgus monkeys and enables simultaneous disruption of two target genes in one step, and no off-target mutagenesis was detected by comprehensive analysis. Expand
Epigenetics The New Kid on the Block
The foundation of the laws of inheritance was established by the Austrian monk Gregor Mendel in the nineteenth century when he conducted hybridization experiments in Pisum sativum (garden peas). TheExpand
CRISPR-Cas systems for editing, regulating and targeting genomes
TLDR
A modified version of the CRISPR-Cas9 system has been developed to recruit heterologous domains that can regulate endogenous gene expression or label specific genomic loci in living cells, which will undoubtedly transform biological research and spur the development of novel molecular therapeutics for human disease. Expand
In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
TLDR
An efficient method to induce specific chromosomal rearrangements in vivo using viral-mediated delivery of the CRISPR/Cas9 system to somatic cells of adult animals is described, substantially expands the ability to model human cancers in mice and potentially in other organisms. Expand
“The Moral Difference between Intragenic and Transgenic Modification of Plants”
  • B. Myskja
  • Biology, Medicine
  • Journal of agricultural & environmental ethics
  • 2006
TLDR
It is suggested that staying within species borders by strengthening endogenous traits reduces the risks and scientific uncertainty, and the main moral reason for intragenic modification is the need to respect the “otherness” of nature. Expand
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
TLDR
The CRISPR/Cas system allows the one-step generation of animals carrying mutations in multiple genes, an approach that will greatly accelerate the in vivo study of functionally redundant genes and of epistatic gene interactions. Expand
Epigenetics and Evolutionary Mechanisms
TLDR
An attempt to incorporate recent knowledge of epigenetics into the evolutionary theory is presented, and drift, selection and epigenetics become inseparable, and their interplay is thought to be needed for the evolution of complex gene regulatory systems. Expand
In vivo gene editing in dystrophic mouse muscle and muscle stem cells
TLDR
A direct gene-editing approach is developed and tested to induce exon deletion and recover dystrophin expression in the mdx mouse model of DMD and partially recovered muscle functional deficiencies and generated a pool of endogenously corrected myogenic precursors in m dx mouse muscle. Expand
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