Human Ebola virus infection results in substantial immune activation.

@article{McElroy2015HumanEV,
  title={Human Ebola virus infection results in substantial immune activation.},
  author={Anita K McElroy and Rama S Akondy and C William Davis and Ali H. Ellebedy and Aneesh K Mehta and Colleen S Kraft and G Marshall Lyon and Bruce S. Ribner and Jay B. Varkey and John Sidney and Alessandro Sette and Shelley Campbell and Ute Str{\"o}her and Inger K. Damon and Stuart T Nichol and Christina F Spiropoulou and Rafi Ahmed},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 15},
  pages={4719-24}
}
Four Ebola patients received care at Emory University Hospital, presenting a unique opportunity to examine the cellular immune responses during acute Ebola virus infection. We found striking activation of both B and T cells in all four patients. Plasmablast frequencies were 10-50% of B cells, compared with less than 1% in healthy individuals. Many of these proliferating plasmablasts were IgG-positive, and this finding coincided with the presence of Ebola virus-specific IgG in the serum… CONTINUE READING
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