Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains.

@article{Yet1998HumanEA,
  title={Human EZF, a Kr{\"u}ppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains.},
  author={S F Yet and M M McA'Nulty and Sara C Folta and Huan W. Yen and Masanori Yoshizumi and Chuen M. Hsieh and Matthew D Layne and Michael T. Chin and Haihong Wang and Mark A. Perrella and Mukesh K Jain and Margaret E. Lee},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 2},
  pages={1026-31}
}
Members of the erythroid Krüppel-like factor (EKLF) multigene family contain three C-terminal zinc fingers, and they are typically expressed in a limited number of tissues. EKLF, the founding member, transactivates the beta-globin promoter by binding to the CACCC motif. EKLF is essential for expression of the beta-globin gene as demonstrated by gene deletion experiments in mice. Using a DNA probe from the zinc finger region of EKLF, we cloned a cDNA encoding a member of this family from a human… CONTINUE READING
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