Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.

@article{Morita2007HumanEA,
  title={Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.},
  author={Eiji Morita and Virginie Sandrin and Hyo-Young Chung and Scott G. Morham and Steven P Gygi and Christopher K Rodesch and Wesley I. Sundquist},
  journal={The EMBO journal},
  year={2007},
  volume={26 19},
  pages={4215-27}
}
  • Eiji Morita, Virginie Sandrin, +4 authors Wesley I. Sundquist
  • Published 2007 in The EMBO journal
TSG101 and ALIX both function in HIV budding and in vesicle formation at the multivesicular body (MVB), where they interact with other Endosomal Sorting Complex Required for Transport (ESCRT) pathway factors required for release of viruses and vesicles. Proteomic analyses revealed that ALIX and TSG101/ESCRT-I also bind a series of proteins involved in cytokinesis, including CEP55, CD2AP, ROCK1, and IQGAP1. ALIX and TSG101 concentrate at centrosomes and are then recruited to the midbodies of… CONTINUE READING
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