Human ESCRT-III and VPS 4 proteins are required for centrosome and spindle maintenance

  • Eiji Moritaa, Leremy A. Colfa, Mary Anne Karrena, Virginie Sandrina, Christopher K. Rodeschb, Wesley I. Sundquista
  • Published 2010


The ESCRT pathway helps mediate the final abscission step of cytokinesis in mammals and archaea. In mammals, two early acting proteins of the ESCRT pathway, ALIX and TSG101, are recruited to the midbody through direct interactions with the phosphoprotein CEP55. CEP55 resides at the centrosome through most of the cell cycle but then migrates to the midbody… (More)

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