Human E2F5 gene is oncogenic in primary rodent cells and is amplified in human breast tumors.

@article{Polanowska2000HumanEG,
  title={Human E2F5 gene is oncogenic in primary rodent cells and is amplified in human breast tumors.},
  author={Jolanta Polanowska and Laurent Le Cam and B{\'e}atrice Orsetti and H{\'e}l{\`e}ne Vall{\'e}s and Eric Fabbrizio and Lluis Fajas and Sylvie Taviaux and Charles Theillet and Claude Sardet},
  journal={Genes, chromosomes & cancer},
  year={2000},
  volume={28 1},
  pages={126-30}
}
E2F transcription factors (E2F1 to 6) are central players in the control of animal cell proliferation as regulators of genes involved in cell cycle progression and in transformation. In this report, we have investigated the potential involvement of the E2F5 gene in tumorigenesis. We show that E2F5 can promote the formation of morphologically transformed foci in primary baby rat kidney cells (BRK) when it is overexpressed in the presence of its heterodimeric partner DP1 and activated RAS. This… CONTINUE READING
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