Human Disease Isolates of Serotype M4 and M22 Group A Streptococcus Lack Genes Required for Hyaluronic Acid Capsule Biosynthesis

@inproceedings{Flores2012HumanDI,
  title={Human Disease Isolates of Serotype M4 and M22 Group A Streptococcus Lack Genes Required for Hyaluronic Acid Capsule Biosynthesis},
  author={Anthony R. Flores and Brittany E. Jewell and Nahuel Fittipaldi and Stephen B Beres and James M. Musser},
  booktitle={mBio},
  year={2012}
}
UNLABELLED Group A streptococcus (GAS) causes human pharyngitis and invasive infections and frequently colonizes individuals asymptomatically. Many lines of evidence generated over decades have shown that the hyaluronic acid capsule is a major virulence factor contributing to these infections. While conducting a whole-genome analysis of the in vivo molecular genetic changes that occur in GAS during longitudinal human pharyngeal interaction, we discovered that serotypes M4 and M22 GAS strains… CONTINUE READING
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The epidemiology of invasive group A Streptococcal infection and potential vaccine

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