Human Dermal Safety Studies with Eflornithine HCl 13.9% Cream (Vaniqa™), a Novel Treatment for Excessive Facial Hair

@article{Hickman2001HumanDS,
  title={Human Dermal Safety Studies with Eflornithine HCl 13.9\% Cream (Vaniqa{\texttrademark}), a Novel Treatment for Excessive Facial Hair},
  author={J. Hickman and F. Huber and M. Palmisano},
  journal={Current Medical Research and Opinion},
  year={2001},
  volume={16},
  pages={235 - 244}
}
Summary Eflornithine HCl 13.9% cream (Vaniqa™) is a novel treatment for the management of unwanted facial hair in women. This paper reports the results of four modified open-label, within-subject vehicle-controlled studies evaluating the dermal safety of this topical treatment. In a repeated insult patch test (230 subjects), erythema with oedema occurred in 38.9% of subjects treated with eflornithine HCl 13.9% cream and 4.8% of subjects treated with vehicle cream. Challenge applications at… Expand
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References

SHOWING 1-10 OF 13 REFERENCES
The development of allergic contact dermatitis in females during the comparison of two predictive patch tests
TLDR
These studies show that females develop significantly more cell‐mediated immune responses to some chemical haptenes than men and the data also points to an overall higher rate of haptene recognition. Expand
A comparison of rabbit and human skin response to certain irritants.
TLDR
The Draize rabbit test accurately predicted the severe human skin irritant and nonirritants, but failed to separate the mild and moderate skin irritants. Expand
Temporary hair removal in patients with hirsutism: a clinical study.
TLDR
It was found that shaving was the most helpful and most frequently used temporary method for hair removal and the use of hydrocortisone 1 percent cream was important in the management of any irritation due to hair removal techniques. Expand
The identification of phototoxic drugs by human assay.
TLDR
This paper is exclusively concerned with phototoxic reactions which follow the oral or parenteral use of drugs, and contact phototoxicity after topical application will be ignored herein. Expand
Textbook of Dermatology
  • R. Warin
  • Bristol Medico-Chirurgical Journal
  • 1987
This book was first published in 1968 by the first three listed editors with the aim of providing a comprehensive account of clinical dermatology, but introducing each chapter with an up-to-dateExpand
Ornithine decarboxylase activity in relation to DNA synthesis in mouse interfollicular epidermis and hair follicles.
TLDR
It was found that, in hair follicles, the variations of DNA replicative activity, which are reflected in the cyclic growth of hair, are paralleled by corresponding changes in ornithine decarboxylase activity. Expand
Quality of life of hirsute women.
TLDR
The results suggest that the complex management of hirsute women, in addition to pharmacological and/or cosmetic measures, may require specific psychotherapy. Expand
Advances in the diagnosis and treatment of the hirsute patient.
TLDR
Current methods of diagnosis and recent advances in the medical treatment of hirsutism and hyperandrogenemia are discussed, including the use of gonadotropin-releasing hormone analogs, flutamide, spironolactone, finasteride, and ketoconazole. Expand
Psychosomatic assessment of hirsute women.
TLDR
The majority of patients showed a good psychological adaptation to illness: they did not report significantly more anxiety, depression, and abnormal illness behavior than controls, but one-sixth of the patients suffered from a clinically meaningful affective disorder. Expand
Hirsutism: evaluation and management
Many women are distressed by what they regard as an abnormal growth of hair. In order to advise them properly one needs to have a clear understanding of the two types of hair which exist and of theirExpand
...
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...