Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages

@inproceedings{McGovern2014HumanDC,
  title={Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages},
  author={Naomi McGovern and Andreas Bernhard Schlitzer and M. Hendro Gunawan and Laura Jardine and Amanda Shin and Elizabeth Poyner and Kile J Green and Rachel Emma Dickinson and Xiao-Nong Wang and Donovan Kian Soon Low and Katie E. Best and Samuel F Covins and P. I. Milne and Sarah Pagan and Khadija Aljefri and Martin Windebank and Diego Miranda Saavedra and Anis Larbi and Pavandip Singh Wasan and Kaibo Duan and Michael Poidinger and Venetia Bigley and Florent Ginhoux and Matthew Collin and Muzlifah Haniffa},
  booktitle={Immunity},
  year={2014}
}
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1⁺ CLEC9A⁺ DCs and CD1c⁺ DCs are murine CD103⁺ DCs and CD64⁻ CD11b⁺ DCs. In addition, human tissues also contain CD14⁺ cells, currently designated as DCs, with an as-yet unknown murine counterpart. Here we have demonstrated that human dermal CD14⁺ cells are a tissue-resident population of monocyte… CONTINUE READING
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