Human Definitive Haemogenic Endothelium and Arterial Vascular Endothelium Represent Distinct Lineages


The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) will depend on the accurate recapitulation of embryonic haematopoiesis. In the early embryo, HSCs develop from the haemogenic endothelium (HE) and are specified in a Notch-dependent manner through a process named endothelial-to-haematopoietic transition (EHT). As HE… (More)
DOI: 10.1038/ncb3161


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