Human Decidua‐Associated Protein (hDP) 200 Identified as a Monoclonal Rheumatoid Factor Is Not an Acute Phase Reactant

  title={Human Decidua‐Associated Protein (hDP) 200 Identified as a Monoclonal Rheumatoid Factor Is Not an Acute Phase Reactant},
  author={R. Halperin and D. Schneider and R. Maymon and I. Bukovsky and E. Hadas},
  journal={American Journal of Reproductive Immunology},
PROBLEM: The role of human decidua associated protein (hDP) 200, identified as a monoclonal rheumatoid factor, has not been determined yet. This study examines if this protein, being an immunoglobulin, participates in the inflammatory processes involving the uterus. 
5 Citations
The Level of Human Decidua‐Associated Protein (hDP) 200, Identified as a Monoclonal Rheumatoid Factor in the Fallopian Tube
Whether ectopic pregnancy is associated with increased levels of human decidua‐associated protein (hDP) 200, identified as a monoclonal rheumatoid factor, in the related fallopian tube as compared with normal tubes is examined. Expand
Human Decidua‐associated Protein 200 Neutralizes the Detrimental Effect of Serum Containing Antiphospholipid Antibodies on Fetal Survival in the Rat
Whether the detrimental effect of serum containing antiphospholipid antibodies on rat pregnancy outcome can be neutralized by addition of human decidua‐associated protein (hDP) 200, a kind of rheumatoid factor, extracted from decidual tissue is examined. Expand
Measurement of Intrauterine Human Decidua-Associated Protein 200 and Diagnosis of Ectopic Pregnancy
Intrauterine hDP 200 is not sufficiently discriminative to be of clinical value in the diagnosis of ectopic pregnancy, and a trend towards lower levels of uterine fluid hDP200 was noted in the group of patients presenting with tubal pregnancy. Expand
Effect of intrauterine injection of casein on fetal survival in rat: a new pharmacological approach for contraception.
The data suggest a new pharmacological approach for contraception, based on local intrauterine effect of alpha-casein in an experimental rat model, and the exact mechanism of action related to casein should be further studied. Expand
Effect of normal rat serum injected into the uterus on fetal survival in the rat
The rat can provide a suitable animal model for further studies and has found an effect of normal rat serum on fetal resorption rate and fetal viability, according to the consistency of this effect. Expand


Sequential Measurements of Human Decidua‐Associated Protein (hDP) 200 in the Uterine Fluid During the Menstrual Cycle
PROBLEM: To examine the relationship between the concentration of uterine fluid human decidua‐associated protein (hDP) 200, identified as a monoclonal rheumatoid factor, and different phases of theExpand
Rheumatoid factor-associated high-molecular-weight complexes in the menstrual and amniotic fluids.
It is possible that complexing of the immunoglobulins by hDP200 serves as one of the mechanisms that ensure suppression of the immune response to fetal antigens. Expand
Human decidua-associated protein hDP200 appears to be a rheumatoid factor.
The amino acid sequences of the amino-terminal of the two different polypeptide chains of the human decidua-associated protein hDP200 revealed that it is an immunoglobulin heavy chain, of the VH-III subgroup and the amino -terminal sequence of the 25 kDa chain showed that it was a human kappa V-III light chain. Expand
Identification, immunoaffinity purification and partial characterization of a human decidua-associated protein.
The data suggest that hDP200 is a novel human decidua-associated protein that did not react with polyclonal antibodies specific for PP12 and PP14 and is suggested to be a subunit of the hDP55. Expand
In situ characterization of leukocytes in the fallopian tube in women with or without an intrauterine contraceptice device
Histological evaluation of sections from the human fallopian tube revealed an inflammatory reaction in 21 of 31 women using an intrauterine contraceptive device (IUCD) and in four of 29 controlsExpand
Human decidua-associated protein hDP200 in menstrual fluid: comparison between fertile women and women after failed in-vitro fertilization/embryo transfer treatment.
Findings support the concept that adequate endometrial function, as evaluated by menstrual fluid concentration of hDP200, is important for the success of the fertility process. Expand
Uterine fluid human decidua-associated protein 200 and implantation after embryo transfer.
Results indicate that hDP 200, identified as a rheumatoid factor secreted by the endometrium, may be involved in the implantation process. Expand
Effect of the intrauterine contraceptive device on protein components of human uterine fluid.
The secretory proteins rather than the transudation products differed between patients who showed IUD-associated side effects vs. those who did not, implying that Iud-related pathology is primarily associated with changes in local secretory response. Expand
Levels of immunoglobulins in the serum and uterine fluid of women using an intrauterine contraceptive device.
The results suggest that secretory immunoglobulins may play a significant role in physiopathological mechanisms associated with the contraceptive action of IUDs. Expand
Secretory immune system of the female reproductive tract. II. Local immune system in normal and infected fallopian tube.
Data suggest that a local immune system is functioning in the human fallopian tube and may provide a first line of defense against tubal infection and the prevention of tubal factor infertility. Expand