Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus.

@article{Chaudhuri2001HumanDR,
  title={Human DNA replication initiation factors, ORC and MCM, associate with oriP of Epstein-Barr virus.},
  author={Biswendu Chaudhuri and Honglin Xu and Ivan Todorov and Anindya Dutta and John L. Yates},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 18},
  pages={10085-9}
}
The 165-kb chromosome of Epstein-Barr virus (EBV) is replicated by cellular enzymes only once per cell cycle in human cells that are latently infected. Here, we report that the human origin recognition complex, ORC, can be detected in association with an EBV replication origin, oriP, in cells by using antibodies against three different subunits of human ORC to precipitate crosslinked chromatin. Mcm2, a subunit of the MCM replication licensing complex, was found to associate with oriP during G(1… CONTINUE READING

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