Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol.

@article{Takata2006HumanDP,
  title={Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol.},
  author={Kei-ichi Takata and Tatsuhiko Shimizu and Shigenori Iwai and Richard D Wood},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 33},
  pages={23445-55}
}
Human DNA polymerase N (POLN or pol nu) is the most recently discovered nuclear DNA polymerase in the human genome. It is an A-family DNA polymerase related to Escherichia coli pol I, human POLQ, and Drosophila Mus308. We report the first purification of the recombinant enzyme and examination of its biochemical properties, as a step toward understanding the… CONTINUE READING