Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks

@inproceedings{Liang2008HumanDL,
  title={Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks},
  author={Li Liang and Li Deng and Son C Nguyen and Xin Zhao and Christopher D. Maulion and Changshun Shao and Jay A. Tischfield},
  booktitle={Nucleic acids research},
  year={2008}
}
DNA nonhomologous end-joining (NHEJ) and homologous recombination are two distinct pathways of DNA double-strand break repair in mammalian cells. Biochemical and genetic studies showed that DNA ends can also be joined via microhomology-mediated end joining (MHEJ), especially when proteins responsible for NHEJ, such as Ku, are reduced or absent. While it has been known that Ku-dependent NHEJ requires DNA ligase IV, it is unclear which DNA ligase(s) is required for Ku-independent MHEJ. In this… CONTINUE READING

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