Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini.

@article{Washington2002HumanDD,
  title={Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini.},
  author={M. Todd Washington and Robert E. Johnson and L. T. Om Prakash and Satya Prakash},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 4},
  pages={1910-4}
}
Both in yeast and humans, DNA polymerase (Pol) (eta) functions in the error-free replication of UV-damaged DNA, and Pol(eta) has the unique ability to efficiently replicate through a cis-syn thymine-thymine (T-T) dimer by inserting two As opposite the two Ts of the dimer. Although human DINB1-encoded Pol(kappa) belongs to the same protein family as Pol(eta), Pol(kappa) shows no ability to bypass this DNA lesion and its biological function has remained unclear. Here, we examine Pol(kappa) for… CONTINUE READING