Human DBS sampling with LC-MS/MS for enantioselective determination of metoprolol and its metabolite O-desmethyl metoprolol.

@article{Liang2010HumanDS,
  title={Human DBS sampling with LC-MS/MS for enantioselective determination of metoprolol and its metabolite O-desmethyl metoprolol.},
  author={Xiaorong Liang and Hongliang Jiang and Xi Chen},
  journal={Bioanalysis},
  year={2010},
  volume={2 8},
  pages={1437-48}
}
BACKGROUND The dried blood spots (DBS) sampling technique has been gaining wide interest in preclinical and clinical studies due to its inherent advantages. However, the impact of DBS sampling on chiral compounds in terms of stability and detection sensitivity has not been studied yet. RESULTS A high-throughput, sensitive and enantioselective LC-MS/MS… CONTINUE READING