• Published 1995

Human Cytomegalovirus Upregulates NFk B Activity by Transactivating the NFk B p 105 / p 50 and p 65 Promoters

@inproceedings{Yurochko1995HumanCU,
  title={Human Cytomegalovirus Upregulates NFk B Activity by Transactivating the NFk B p 105 / p 50 and p 65 Promoters},
  author={Andrew D Yurochko and Timothy F. Kowalik and S M Huong and E Huang},
  year={1995}
}
During human cytomegalovirus (HCMV) infection, a series of regulated events take place following virus binding and entry into the cell, including the upregulation of cellular transcription factors, such as NF-kB, which play an essential role in the viral life cycle. We show here that NF-kB message is induced during HCMV infection and that the induction is biphasic, suggesting an initial induction at immediate-early (IE) times and a second round of induction at early times. This hypothesis is… CONTINUE READING

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References

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Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection.

VIEW 10 EXCERPTS

The NF-kB p65 promoter

  • K. Ueberla, Y. Lu, E. Chung, W. A. Haseltine
  • J. Acquired Immune Defic. Syndr
  • 1993
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

In vivo and in vitro analysis of transcriptional activation mediated by the human cytomegalovirus major immediate-early proteins

  • K. M. Klucher, M. Sommer, J. T. Kadonga, D. H. Spector
  • Mol. Cell. Biol
  • 1993
VIEW 4 EXCERPTS
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