Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity

@article{Seo2011HumanCD,
  title={Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity},
  author={Jun-Young Seo and Rakina Yaneva and Ella R. Hinson and Peter Cresswell},
  journal={Science},
  year={2011},
  volume={332},
  pages={1093 - 1097}
}
Human cytomegalovirus uses a host-encoded antiviral protein to its own advantage. Viperin is an interferon-inducible protein that is directly induced in cells by human cytomegalovirus (HCMV) infection. Why HCMV would induce viperin, which has antiviral activity, is unknown. We show that HCMV-induced viperin disrupts cellular metabolism to enhance the infectious process. Viperin interaction with the viral protein vMIA resulted in viperin relocalization from the endoplasmic reticulum to the… 

Viperin Regulates Cellular Lipid Metabolism during Human Cytomegalovirus Infection

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The function and evolution of the restriction factor viperin in primates was not driven by lentiviruses

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Interplay between Human Cytomegalovirus and Intrinsic/Innate Host Responses: A Complex Bidirectional Relationship

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