• DOI:10.1126/science.1202007
Corpus ID: 22293459

Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity

@article{Seo2011HumanCD,
  title={Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity},
  author={Jun-Young Seo and R. Yaneva and E. Hinson and P. Cresswell},
  journal={Science},
  year={2011},
  volume={332},
  pages={1093 - 1097}
}

Jun-Young Seo, R. Yaneva, +1 author P. Cresswell

Published 2011

Biology, Medicine

Science

Human cytomegalovirus uses a host-encoded antiviral protein to its own advantage. Viperin is an interferon-inducible protein that is directly induced in cells by human cytomegalovirus (HCMV) infection. Why HCMV would induce viperin, which has antiviral activity, is unknown. We show that HCMV-induced viperin disrupts cellular metabolism to enhance the infectious process. Viperin interaction with the viral protein vMIA resulted in viperin relocalization from the endoplasmic reticulum to the… CONTINUE READING

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