Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity

  title={Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity},
  author={Jun-Young Seo and R. Yaneva and E. Hinson and P. Cresswell},
  pages={1093 - 1097}
  • Jun-Young Seo, R. Yaneva, +1 author P. Cresswell
  • Published 2011
  • Biology, Medicine
  • Science
  • Human cytomegalovirus uses a host-encoded antiviral protein to its own advantage. Viperin is an interferon-inducible protein that is directly induced in cells by human cytomegalovirus (HCMV) infection. Why HCMV would induce viperin, which has antiviral activity, is unknown. We show that HCMV-induced viperin disrupts cellular metabolism to enhance the infectious process. Viperin interaction with the viral protein vMIA resulted in viperin relocalization from the endoplasmic reticulum to the… CONTINUE READING
    153 Citations

    Paper Mentions

    Viperin Regulates Cellular Lipid Metabolism during Human Cytomegalovirus Infection
    • 77
    • PDF
    Targeting Viperin to the Mitochondrion Inhibits the Thiolase Activity of the Trifunctional Enzyme Complex
    • 3
    • Highly Influenced
    • PDF
    Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex
    • 1
    • Highly Influenced
    • PDF
    Human Cytomegalovirus Exploits Interferon-Induced Transmembrane Proteins To Facilitate Morphogenesis of the Virion Assembly Compartment
    • 37
    • PDF
    The Interaction Mechanism Between Herpes Simplex Virus 1 Glycoprotein D and Host Antiviral Protein Viperin
    • 6
    • Highly Influenced
    • PDF
    Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein
    • 9
    • PDF
    The function and evolution of the restriction factor viperin in primates was not driven by lentiviruses
    • 27
    Ovine viperin inhibits bluetongue virus replication.


    Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus
    • K. C. Chin, P. Cresswell
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2001
    • 351
    • PDF
    Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA
    • 86
    • PDF
    A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.
    • 417
    • PDF
    vMIA, a viral inhibitor of apoptosis targeting mitochondria.
    • 73
    The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic α-helix
    • 173
    • PDF
    Cytoskeletal disruption during human cytomegalovirus infection of human lung fibroblasts.
    • 44