Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma

@article{Wechselberger2005HumanCO,
  title={Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma},
  author={Christian Wechselberger and Luigi Strizzi and Nicholas Kenney and Morihisa Hirota and Youping Sun and Andreas D. Ebert and Olivia E Orozco and Carmelina Bianco and Nadia Inji Khan and Brenda Wallace-Jones and Nicola Normanno and Heather B. Adkins and Michele Sanicola and David Scott Salomon},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={4094-4105}
}
Human Cripto-1 (CR-1) is overexpressed in approximately 80% of human breast, colon and lung carcinomas. Mouse Cr-1 upregulation is also observed in a number of transgenic (Tg) mouse mammary tumors. To determine whether CR-1 can alter mammary gland development and/or may contribute to tumorigenesis in vivo, we have generated Tg mouse lines that express human CR-1 under the transcriptional control of the mouse mammary tumor virus (MMTV). Stable Tg MMTV/CR-1 FVB/N lines expressing different levels… CONTINUE READING
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