Human-Compatible Animal Models for Preclinical Research on Hormones in Breast Cancer

  title={Human-Compatible Animal Models for Preclinical Research on Hormones in Breast Cancer},
  author={K. Gregerson},
Abstract : Our most significant findings during the second year of work included the following: 1. The PRL-humanized mice synthesize and secrete hPRL that is fully biologically active at the human PRL receptor as evidenced by activation of STAT5 in human breast cancer cells. 2. Our proof of concept experiment in which human breast cancer xenografts were studied in hosts bearing anterior pituitary grafts under the renal capsules, supports the hypothesis that elevated circulating hPRL leads to… Expand


Novel roles of prolactin and estrogens in breast cancer: resistance to chemotherapy.
Evidence that low doses of PRL, estradiol (E(2)), and bisphenol A (BPA) antagonize multiple anticancer drugs that induce cell death by different mechanisms is reviewed. Expand
Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells
A role of Stat5 as a suppressor of breast cancer invasion and metastatic progression provides a biological mechanism to explain the favorable prognosis associated with active Stat5 in human breast cancer. Expand
Biological Characterization of Mice Expressing the Human Prolactin Gene
  • FASEB SRC on The GH/PRL Family in Biology and Disease, July 8-­‐13,
  • 2012
Human-­‐Compatible Animals Models for Preclinical
  • Research on Prolactin in Breast Cancer”,
  • 2011