Human-Compatible Animal Models for Preclinical Research on Hormones in Breast Cancer

@inproceedings{Gregerson2012HumanCompatibleAM,
  title={Human-Compatible Animal Models for Preclinical Research on Hormones in Breast Cancer},
  author={K. Gregerson},
  year={2012}
}
Abstract : Our most significant findings during the second year of work included the following: 1. The PRL-humanized mice synthesize and secrete hPRL that is fully biologically active at the human PRL receptor as evidenced by activation of STAT5 in human breast cancer cells. 2. Our proof of concept experiment in which human breast cancer xenografts were studied in hosts bearing anterior pituitary grafts under the renal capsules, supports the hypothesis that elevated circulating hPRL leads to… Expand

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