Human Claudin-8 and -14 Are Receptors Capable of Conveying the Cytotoxic Effects of Clostridium perfringens Enterotoxin

@inproceedings{Shrestha2013HumanCA,
  title={Human Claudin-8 and -14 Are Receptors Capable of Conveying the Cytotoxic Effects of Clostridium perfringens Enterotoxin},
  author={Archana Shrestha and Bruce A McClane},
  booktitle={mBio},
  year={2013}
}
UNLABELLED Clostridium perfringens enterotoxin (CPE) contributes to several important human gastrointestinal (GI) diseases. This toxin and its derivatives are also being explored for translational applications, i.e., cancer therapy or drug delivery. Some, but not all, members of the 24-member claudin (Cldn) family of mammalian tight junction proteins can serve as CPE receptors. Among the human Cldns (hCldns), hCldn-3 and -4 are known to convey CPE sensitivity when expressed by fibroblast… CONTINUE READING
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Clostridium perfringens, p 465– 489

  • BA McClane, SL Robertson, J. Li
  • Food microbiology: fundamentals and frontiers,
  • 2013
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