Human Chitotriosidase: a Sensitive Biomarker of Sarcoidosis

  title={Human Chitotriosidase: a Sensitive Biomarker of Sarcoidosis},
  author={Elena Bargagli and David Bennett and Claudia Maggiorelli and Pasquale Di Sipio and Maria Antonietta Margollicci and Nicola Bianchi and Paola Rottoli},
  journal={Journal of Clinical Immunology},
Sarcoidosis is a multisystem granulomatous disease of unknown etiology. No suitable biomarkers are available to evaluate the evolution of this disease, which still has an unpredictable clinical course. Some years ago our research group proposed chitotriosidase as a potential biomarker with prognostic value, that however needed to be validated. The aims of this study were to evaluate the sensitivity and specificity of chitotriosidase in a population of 232 sarcoidosis patients under the… CONTINUE READING


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