Human-Chimpanzee Differences in a FZD 8 Enhancer Alter Cell-Cycle Dynamics in the Developing Neocortex Graphical

@inproceedings{Boyd2015HumanChimpanzeeDI,
  title={Human-Chimpanzee Differences in a FZD 8 Enhancer Alter Cell-Cycle Dynamics in the Developing Neocortex Graphical},
  author={J. Lomax Boyd and Stephanie L. Skove and Jeremy P. Rouanet and Louis-Jan Pilaz and Tristan Bepler and Raluca Gord{\^a}n and Gregory A. Wray and Debra L Silver},
  year={2015}
}
Graphical Abstract Highlights d Discovery of a human-accelerated enhancer functioning in the developing neocortex d Compared to chimpanzee, human HARE5 drives earlier and more robust brain expression d The HARE5 locus physically contacts the core promoter of the WNT receptor, Fzd8 d HARE5::Fzd8 mice have an accelerated neural progenitor cell cycle and… CONTINUE READING