Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C.

@article{McNulty2017HumanCP,
  title={Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C.},
  author={Shannon M McNulty and Lori L. Sullivan and Beth A Sullivan},
  journal={Developmental cell},
  year={2017},
  volume={42 3},
  pages={
          226-240.e6
        }
}
Human centromeres are defined by alpha satellite DNA arrays that are distinct and chromosome specific. Most human chromosomes contain multiple alpha satellite arrays that are competent for centromere assembly. Here, we show that human centromeres are defined by chromosome-specific RNAs linked to underlying organization of distinct alpha satellite arrays. Active and inactive arrays on the same chromosome produce discrete sets of transcripts in cis. Non-coding RNAs produced from active arrays are… CONTINUE READING
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Chromosome-specific organization of human alpha satellite DNA.

American journal of human genetics • 1985
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