Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

  title={Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria},
  author={Heather A. Feaga and Michael D. Quickel and Pamela A Hankey-Giblin and Kenneth C Keiler},
  booktitle={PLoS genetics},
Bacteria use trans-translation and the alternative rescue factors ArfA (P36675) and ArfB (Q9A8Y3) to hydrolyze peptidyl-tRNA on ribosomes that stall near the 3' end of an mRNA during protein synthesis. The eukaryotic protein ICT1 (Q14197) is homologous to ArfB. In vitro ribosome rescue assays of human ICT1 and Caulobacter crescentus ArfB showed that these proteins have the same activity and substrate specificity. Both ArfB and ICT1 hydrolyze peptidyl-tRNA on nonstop ribosomes or ribosomes… CONTINUE READING
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Mechanisms of ribosome rescue in bacteria

Nature Reviews Microbiology • 2015
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