Human Cancer Biology Surveillance of the Tumor Mutanome by T Cells during Progression from Primary to Recurrent Ovarian Cancer

Abstract

Purpose:Cancers accumulatemutations over time, each of which brings the potential for recognition by the immune system.We evaluated T-cell recognitionof the tumormutanome inpatientswithovarian cancer undergoing standard treatment. Experimental Design: Tumor-associated T cells from 3 patients with ovarian cancer were assessed by ELISPOT for recognition of… (More)

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