Human Cancer Biology LAP þ CD 4 þ T Cells Are Suppressors Accumulated in the Tumor Sites and Associated with the Progression of Colorectal Cancer

@inproceedings{Mahalingam2012HumanCB,
  title={Human Cancer Biology LAP þ CD 4 þ T Cells Are Suppressors Accumulated in the Tumor Sites and Associated with the Progression of Colorectal Cancer},
  author={Jayashri Mahalingam and Yung-Chang Lin and Jy-Ming Chiang and Po-Jung Su and Jian-He Fang and Yu-Yi Chu and Ching-Tai Huang and Cheng-Tang Chiu and Chun-Yen Lin},
  year={2012}
}
Purpose: Suppressor T cells are one of the determinants of colorectal cancer (CRC) clinical outcome. LAPþCD4þ T cell is a recently identified subset of suppressor T cells. This study was designed to investigate their clinical relevance in patients with CRC. Experimental Design: Sixty patients with CRC and 24 healthy donors (HD) were enrolled in this study. The percentages of LAPþCD4þ T cells in peripheral blood and tumor tissue were measured. The phenotype and functional relevance of LAPþCD4þ T… CONTINUE READING

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