Human Cancer Biology Global Hypomethylation Identifies Loci Targeted for Hypermethylation in Head and Neck Cancer

Abstract

Purpose: The human epigenome is profoundly altered in cancers, with a characteristic loss of methylation in repetitive regions and concomitant accumulation of gene promoter methylation. The degree to which these processes are coordinated is unclear so we investigated both in head and neck squamous cell carcinomas. Experimental Design: Global methylation was… (More)

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