Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.

@article{Zoellner2009HumanCC,
  title={Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.},
  author={Andy Zoellner and C Dragan and Dominik Pistorius and Rolf M{\"u}ller and Helge B Bode and Frank T Peters and Hans H Maurer and Matthias Bureik},
  journal={Biological chemistry},
  year={2009},
  volume={390 4},
  pages={313-7}
}
Overexpression of human CYP4Z1, a cytochrome P450 enzyme, has been correlated with poor prognosis in human cancer. However, its catalytic properties are not yet known. We expressed this P450 in Schizosaccharomyces pombe and demonstrate by whole-cell biotransformation assays CYP4Z1-dependent in-chain hydroxylation of lauric and myristic acid, which in both cases leads to the formation of four different monohydroxylated products at positions omega-2, omega-3, omega-4, and omega-5, respectively… CONTINUE READING

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