Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.

  title={Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.},
  author={Val{\'e}rie Le Qu{\'e}r{\'e} and Emmanuelle Pl{\'e}e-Gautier and Philippe Potin and St{\'e}phanie Madec and J. -P. Sala{\"u}n},
  journal={Journal of lipid research},
  volume={45 8},
CYP4F isoforms are involved in the oxidation of important cellular mediators such as leukotriene B4 (LTB4) and prostaglandins. The proinflammatory agent LTB4 and cytotoxic leukotoxins have been associated with several inflammatory diseases. We present evidence that the hydroxylation of Z 9(10)-epoxyoctadecanoic, Z 9(10)-epoxyoctadec-Z 12-enoic, and Z 12(13)-epoxyoctadec-Z 9-enoic acids and that of monoepoxides from arachidonic acid [epoxyeicosatrienoic acid (EET)] is important in the regulation… CONTINUE READING


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