Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2.

  title={Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2.},
  author={Shin-Ichi Yokota and Eriko Higashi and Tatsuki Fukami and Tsuyoshi Yokoi and Miki Nakajima},
  journal={Biochemical pharmacology},
  volume={81 2},
Human CYP2A6 is responsible for the metabolism of nicotine and coumarin as well as the metabolic activation of tobacco-related nitrosamines. Earlier studies revealed that CYP2A6 activity was increased by dietary cadmium or cruciferous vegetables, but the underlying mechanisms remain to be clarified. In the present study, we investigated the possibility that Nrf2 might be involved in the regulation of CYP2A6. Real-time RT-PCR analysis revealed that the CYP2A6 mRNA level in human hepatocytes was… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 17 extracted citations

CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.

Drug metabolism and disposition: the biological fate of chemicals • 2015
View 2 Excerpts


Publications referenced by this paper.
Showing 1-10 of 29 references

High cadmium / zinc ratio in cigarette smokers: potential implications as a biomarker of risk of prostate cancer.

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria • 2008
View 1 Excerpt

An association of CYP2A6 genotype and smoking topography.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco • 2007
View 2 Excerpts

Similar Papers

Loading similar papers…