Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation?

@article{Rochat2001HumanCA,
  title={Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation?},
  author={Bertrand Rochat and J. M. Morsman and Graeme I. Murray and William D. Figg and Ping Liao},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={296 2},
  pages={
          537-41
        }
}
The cytochrome P450 1B1 (CYP1B1) is involved in the metabolism of procarcinogens and xenobiotics. Human CYP1B1 protein has been detected in a variety of tumors but is not detected in adjacent normal tissues or in liver. This suggests that CYP1B1 could biotransform anticancer agents specifically in the target cells. The interaction between CYP1B1 and 12 commonly used anticancer drugs was screened using an ethoxyresorufin deethylase assay. Four agents were competitive inhibitors of CYP1B1… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 16 references

Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2.

Drug metabolism and disposition: the biological fate of chemicals • 1997
View 8 Excerpts
Highly Influenced

Oxidation of xenobiotics by recombinant human cytochrome P450 1B1.

Drug metabolism and disposition: the biological fate of chemicals • 1997
View 4 Excerpts
Highly Influenced

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 2 Excerpts
Highly Influenced

Enzymes, 3rd ed

M Dixon, EC Webb
1979
View 2 Excerpts
Highly Influenced

Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society • 1999
View 3 Excerpts

Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 1999
View 2 Excerpts