Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation?

@article{Rochat2001HumanCA,
  title={Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation?},
  author={Bertrand Rochat and J. M. Morsman and Graeme I. Murray and William D. Figg and Ping Liao},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={296 2},
  pages={
          537-41
        }
}

• Bertrand Rochat, J. M. Morsman, +2 authors Ping Liao
• Published 2001 in
  The Journal of pharmacology and experimental…

The cytochrome P450 1B1 (CYP1B1) is involved in the metabolism of procarcinogens and xenobiotics. Human CYP1B1 protein has been detected in a variety of tumors but is not detected in adjacent normal tissues or in liver. This suggests that CYP1B1 could biotransform anticancer agents specifically in the target cells. The interaction between CYP1B1 and 12 commonly used anticancer drugs was screened using an ethoxyresorufin deethylase assay. Four agents were competitive inhibitors of CYP1B1… CONTINUE READING

Save to Library

Create Alert

Cite

View Paper