Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells.

@article{Elinav2012HumanCA,
  title={Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells.},
  author={H Elinav and Yuanfei Wu and Ayse Kivilcim Coskun and Katarzyna Hryckiewicz and Iris Kemler and Yani Hu and Hilary J Rogers and Bing Hao and Choukri Ben Mamoun and Eric M. Poeschla and Richard Hugh Sutton},
  journal={Journal of virology},
  year={2012},
  volume={86 22},
  pages={
          12053-68
        }
}
Productive replication of human immunodeficiency virus type 1 (HIV-1) occurs efficiently only in humans. The posttranscriptional stages of the HIV-1 life cycle proceed poorly in mouse cells, with a resulting defect in viral assembly and release. Previous work has shown that the presence of human chromosome 2 increases HIV-1 production in mouse cells. Recent studies have shown that human chromosome region maintenance 1 (hCRM1) stimulates Gag release from rodent cells. Here we report that… CONTINUE READING

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