Human COL2A1-directed SV40 T antigen expression in transgenic and chimeric mice results in abnormal skeletal development

@article{Cheah1995HumanCS,
  title={Human COL2A1-directed SV40 T antigen expression in transgenic and chimeric mice results in abnormal skeletal development},
  author={Kathryn Song Eng Cheah and Albert Levy and Paul A Trainor and Albert W. K. Wai and Tamara Kuffner and Chi Leong So and Keith K. H. Leung and Robin Lovell-Badge and Patrick P. L. Tam},
  journal={The Journal of Cell Biology},
  year={1995},
  volume={128},
  pages={223 - 237}
}
The ability of SV40 T antigen to cause abnormalities in cartilage development in transgenic mice and chimeras has been tested. The cis-regulatory elements of the COL2A1 gene were used to target expression of SV40 T antigen to differentiating chondrocytes in transgenic mice and chimeras derived from embryonal stem (ES) cells bearing the same transgene. The… CONTINUE READING